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KMID : 0368819960350010163
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Journal of the Korean Neuropsychiatr Association
1996 Volume.35 No. 1 p.163 ~ p.170
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Effect of Ethanol Administration on Immune Response and Tumorigencsis in Mice
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Abstract
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For the investigation of the effect of long-term continuous ethanol(EOH) administration and EOH withdrawal on the immune response potential and sexual dimorphism in the tumorigenesis induced by 3-Methylcholanthrene(MCA), the frequency of tumor
production and the number of tumors per tumor bearing mouse(TBM) in female and male mice were examined. The production of IL-2 and natural killer cell activity(NKCA) of murine splenocyte were also examined. It was found that EOH feeding may
suppress
IL-2 production and NKCA but may enhance tumor growth, and there was a sexual dimorphism in tumor production in mice. It was also found the EOH withdrawal decreased the number of tumors per TBM, and EOH termination did not reverse the depression
of
both
IL-2 production and NKCA caused by the previous EOH feeding.
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